Delayed Hemolytic Transfusion Reaction in Sickle Cell Disease
نویسندگان
چکیده
منابع مشابه
Delayed Hemolytic Transfusion Reaction in Sickle Cell Disease
Patients with sickle cell disease frequently require red blood cell transfusions . However, transfusions can cause delayed hemolytic transfusion reaction (DHTR), a serious and potentially life-threatening complication of alloimmunization that results in hemolysis of transfused as well as patients’ own red cells . Although we are beginning to understand some of the pathophysiology and risk facto...
متن کاملCase reports: delayed hemolytic transfusion reaction in sickle cell disease.
This article reports the details of delayed hemolytic transfusion reactions in four patients with sickle cell disease. These cases demonstrate the characteristics of the reactions, the significant risks involved, and the principles useful in diagnosis and treatment. Patients with sickle cell disease are at particular risk for delayed hemolytic transfusion reactions because they may be transfuse...
متن کاملDelayed hemolytic transfusion reaction in children with sickle cell disease.
BACKGROUND Transfusion is a cornerstone of the management of sickle cell disease but carries a high risk of hemolytic transfusion reaction, probably because of differences in erythrocyte antigens between blood donors of European descent and patients of African descent. Patients may experience hemolytic transfusion reactions that are delayed by from a few days to two weeks and manifest as acute ...
متن کاملRituximab for prevention of delayed hemolytic transfusion reaction in sickle cell disease.
Delayed hemolytic transfusion reaction (DHTR), a life-threatening transfusion complication in sickle cell disease (SCD), is characterized by a marked hemoglobin drop with destruction of both transfused and autologous red blood cells (RBCs) and exacerbation of SCD symptoms. One mechanism of RBCs destruction is auto-antibody production secondary to transfusion. As rituximab specifically targets c...
متن کاملDelayed hemolytic transfusion reaction/hyperhemolysis syndrome in children with sickle cell disease.
OBJECTIVE Alloimmunization in patients with sickle cell disease (SCD) has a reported incidence of 5% to 36%. One complication of alloimmunization is delayed hemolytic transfusion reaction/hyperhemolysis (DHTR/H) syndrome, which has a reported incidence of 11%. In patients with SCD, clinical findings in DHTR/H syndrome occur approximately 1 week after the red blood cell (RBC) transfusion and inc...
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ژورنال
عنوان ژورنال: American Journal of Clinical Medicine Research
سال: 2013
ISSN: 2328-4005
DOI: 10.12691/ajcmr-1-3-2